Call ahead - This is a small river with a limited amount of boats for rent. I had no problem but I would make a reservation to avoid possible disappointment.
Go early - The Canoe Outfitters opens at 8:00 am. We arrived at 8:30 am but still had the entire river to ourselves all the way out to the turnpike bridge. The way back was a totally different story. The river went from slightly congested to packed with novices.
Bring a camera - When else will you have an opportunity to see ancient, giant cypress trees unless you are lost in a swamp. There are also some great wildlife shots along the route.
Dams - There are two. You may be able to slide over them on the way out if the water is high enough but you will need to get out of your boat and drag it back the other way. It's actually a lot of fun even if I totally sunk my kayak on one. A dry bag is a great idea. Wish I had brought mine.
Alligators - They have them and in abundance. They will not eat you unless you are stupid. If you are stupid, and you know who you are, stay home. That goes for noisy, reckless, a litter bug, or just plain ignorant. This river and all the plants and animals who live in it were here long before you were. Try and remember you are visiting their home and use some of that common sense and common courtesy that seems so rare these days.
Skill - That all depends in the water level. On the day I went, it was a bit more challenging. There are obstructions and currents all the way down and back. For me it made the trip worth while. For some canoeing couples, it was putting relationships to the test. I will very likely go back when the water is higher just to see the difference.
Choices - If the river seems too intimidating, going the opposite direction at the start takes you down a wide and extremely flat canal. There is even a picnic area and launching beach if you brought your own boat. Much more suitable if I want to come back with the inflatables another time.
Once the canoe ride was over, I found some very elaborate and well marked walking/bike paths. They are all crushed coral with the occasional bridge. I walked along for a while as I was drying out but decided I would return with the bike and fully explore them soon. Not too far of a drive for a truly unique get-a-way from the big city.